New Colon Cancer Study Results Reported from First Affiliated Hospital of Jinan University (METTL3 recruiting M2-type immunosuppressed macrophages by targeting m6A-SNAIL-CXCL2 axis to promote colorectal cancer pulmonary metastasis).

A recent study conducted at the First Affiliated Hospital of Jinan University explored the role of N6-methyladenosine (m6A) modification in the development of colorectal cancer and its pulmonary metastasis. The researchers found that the METTL3 gene promotes the spread of colorectal cancer to the lungs by modifying the SNAIL mRNA through m6A modification, which leads to the secretion of CXCL2. Additionally, colorectal cancer cells expressing METTL3 recruit M2-type immunosuppressive macrophages. These findings provide new insights into the mechanisms of colorectal cancer metastasis and potential therapeutic targets for treatment. [Extracted from the article]

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