Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis (Updated April 17, 2024).

A recent study conducted on patients with multiple sclerosis (MS) has revealed that defective Integrator activity plays a significant role in shaping the transcriptome of individuals with the disease. The researchers conducted high-depth RNA sequencing on monocytes from a cohort of MS patients and found a markedly altered transcriptome in a subset of patients, coinciding with decreased expression of the epigenetic silencer HP1/CBX5. These patients also exhibited diminished expression of multiple genes encoding subunits of the Integrator complex, suggesting impaired Integrator activity. The study proposes that this impaired activity can provide a mechanistic understanding of the transcriptional anomalies associated with MS. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

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