Recombinant manufacturing of multispecies biolubricants.
In: Health & Medicine Week, 2024-05-24, S. 3968-3968
serialPeriodical
Zugriff:
This article discusses the development of recombinant lubricin analogs, which are lubricating glycoproteins found in synovial fluid. The researchers used rational design to create analogs that have increased biocompatibility and retain the lubricating properties of native lubricin. They also developed a bioprocess chain using a human-derived cell line to produce O-glycosylation consistent with native lubricin and a purification strategy. The study demonstrates the tissue binding capacity of the engineered lubricin product and its retention in the joint space of rats. The findings have potential applications in the treatment of diseases such as osteoarthritis and dry eye disease. [Extracted from the article]
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Titel: |
Recombinant manufacturing of multispecies biolubricants.
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Zeitschrift: | Health & Medicine Week, 2024-05-24, S. 3968-3968 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6459 (print) |
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