Studies from Southeast University Yield New Data on Stroke (Long-term Accumulation of T Cytotoxic 1, T Cytotoxic 17, and T Cytotoxic 17/1 Cells In the Brain Contributes To Microglia-mediated Chronic Neuroinflammation After Ischemic Stroke).

A recent study conducted by researchers at Southeast University in Jiangsu, China, explores the role of T cell subsets in neuroinflammation after ischemic stroke. The study found that CD8(+) T cells were present in the brain in the subacute and late phases of stroke, with an increase in their numbers over time. These CD8(+) T cells produced interferon-gamma (IFN-gamma) on day 3 after stroke and co-expressed IFN-gamma and interleukin-17A (IL-17A) on day 30. The study also identified T cytotoxic 1 (Tc1), T cytotoxic 17 (Tc17), and T cytotoxic 17/1 (Tc17/1) cells in the brain, which contributed to long-term neuroinflammation. The findings suggest that these T cell subsets play a role in the progression of neuroinflammation after stroke. [Extracted from the article]

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