Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM (Updated May 17, 2024).
In: Drug Week, 2024-06-07, S. 420-420
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Zugriff:
A preprint abstract from biorxiv.org discusses the use of a platform called CeTEAM (cellular target engagement by accumulation of mutant) in drug discovery. CeTEAM allows for the simultaneous evaluation of drug-target interactions and phenotypic responses, providing a holistic assessment of drug pharmacology. The study demonstrates the effectiveness of CeTEAM in various applications, such as analyzing drug-responsive proteotypes, dissecting pharmacogenetic variants, and profiling the dynamics of drug binding. The data suggests that CeTEAM can facilitate real-time and comprehensive characterization of target engagement and its biological consequences. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]
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Titel: |
Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM (Updated May 17, 2024).
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Zeitschrift: | Drug Week, 2024-06-07, S. 420-420 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1531-6440 (print) |
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