Investigators at University of Exeter Medical School Detail Findings in Kidney Disease (Recurrent 17q12 Microduplications Contribute To Renal Disease but Not Diabetes).
In: Diabetes Week, 2024-06-24, S. 98-98
serialPeriodical
Zugriff:
A recent study conducted by researchers at the University of Exeter Medical School in the United Kingdom has found that recurrent 17q12 microduplications contribute to renal disease but not diabetes. The study analyzed data from a population-based cohort and identified 11 microdeletions and 106 microduplications in the 17q12 region. Microdeletions were strongly associated with diabetes and decreased renal function, while microduplications were associated with decreased fluid intelligence. The study suggests that HNF1B haploinsufficiency may be the cause of diabetes in individuals with 17q12 microdeletions. However, both microdeletions and microduplications were found to be associated with renal disease, indicating that multiple genes within the region contribute to renal and neurocognitive phenotypes. [Extracted from the article]
Copyright of Diabetes Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Titel: |
Investigators at University of Exeter Medical School Detail Findings in Kidney Disease (Recurrent 17q12 Microduplications Contribute To Renal Disease but Not Diabetes).
|
---|---|
Zeitschrift: | Diabetes Week, 2024-06-24, S. 98-98 |
Veröffentlichung: | 2024 |
Medientyp: | serialPeriodical |
ISSN: | 1537-1425 (print) |
Sonstiges: |
|