Proteomic analysis of GPI-anchored membrane proteins.
In: Drug Discovery Today: Technologies, Jg. 3 (2006-09-01), Heft 3, S. 339-346
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Zugriff:
Glycosyl-phosphatidyl-inositol-anchored proteins (GPI-APs) represent a subset of post-translationally modified proteins that are tethered to the outer leaflet of the plasma membrane via a C-terminal GPI anchor. GPI-APs are found in a variety of eukaryote species, from pathogenic microorganisms to humans. GPI-APs confer important cellular functions as receptors, enzymes and scaffolding molecules. Specific enzymes and detergent extraction methods combined with separation technologies and mass spectrometry permit proteomic analysis of GPI-APs from plasma membrane preparations to reveal cell-type specific surface molecules, candidate biomarkers and potential therapeutic targets. [Copyright &y& Elsevier]
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Proteomic analysis of GPI-anchored membrane proteins.
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Autor/in / Beteiligte Person: | Jung, Hye Ryung ; Jensen, Ole Nørregaard |
Zeitschrift: | Drug Discovery Today: Technologies, Jg. 3 (2006-09-01), Heft 3, S. 339-346 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 1740-6749 (print) |
DOI: | 10.1016/j.ddtec.2006.09.011 |
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