Effect of a somatostatin analog on insulin requirement and hormone levels in 6 insulin-dependent juvenile-onset diabetics subjected to artificial pancreas
In: Acta Diabetologica Latina, Jg. 17 (1980-01-19), Heft 1, S. 9-14
serialPeriodical
Zugriff:
Summary: This study was performed in order to investigate the effect of a 12-h infusion of the somatostatin selective analog D-Trp 3 , D-Cys 14 Serono, (SRIF-A), on insulin requirement and C-peptide (CP), growth hormone (GH) and glucagon (IRG) levels in 6 insulin-dependent diabetics submitted to 60-h artificial pancreas (Biostator Miles) metabolic control from 20 00 of the first day to 08 00 of the fourth day. Meals were given at 12 00 and 17 00 of the second and third day. Before meals and 1–2 h after meals, plasma levels of CP, GH and IRG were measured. The two 12-h periods (midday-midnight) with and without continuous SRIF-A 12-h infusion (40 g/h) were considered. The SRIF-A infusion caused a 20% reduction in insulin requirement (p<0.05) and a slight but significant reduction of GH levels (p<0.05). CP and IRG were unaffected.
Titel: |
Effect of a somatostatin analog on insulin requirement and hormone levels in 6 insulin-dependent juvenile-onset diabetics subjected to artificial pancreas
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Autor/in / Beteiligte Person: | Lenti, Gianfranco ; Trovati, Mariella ; Lorenzati, Riccardo ; Vitelli, Federico ; Tagliaferro, Vittorio ; Marocco, Anna ; Pagano, Gianfranco |
Zeitschrift: | Acta Diabetologica Latina, Jg. 17 (1980-01-19), Heft 1, S. 9-14 |
Veröffentlichung: | 1980 |
Medientyp: | serialPeriodical |
ISSN: | 0001-5563 (print) ; 2385-2631 (print) |
DOI: | 10.1007/BF02582072 |
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